2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005


2022年

Kasahara Y., Narukawa M., Takeuchi A., Tominaga M., Abe K., Asakura T. Molecular logic of salt taste reception in special reference to transmembrane channel-like 4 (TMC4) J. Physiol. Sci. (2022) (72),31 [DOI]

Hiroko Asakura, Shu Taira, Junko Funaki, Takashi Yamakawa, Keiko Abe and Tomiko Asakura. Mass spectorometry imaging analysis of metabolic changes in green and red tomato fruits exposed to drought stress. Applied Sciences 22(1) 216 [DOI]

Reiko Ueda, Kana Umetani, Fumiko Konishi, Anju Mori, Toshitada Nagai, Hiroko Asakura, Junko Funaki, Keiko Abe and Tomiko Asakura. Characterization of palatability and ease of deglutition of the five basic tastes were characterized with partial least squares regression analysis using myoelectric potential parameters of the submental muscle. J. Food Sci. Technol. Res. 28(1)75-86 [DOI]

Yoichi Kasahara, Haruyuki Yamashita, Masataka Narukawa, Keiko Abe, and Tomiko Asakura. 3‑Guanidinyl Propanol Enhances Salt Taste via TMC4-Mediated Current ACS Food Sci. Technol.1213−1216 [DOI]

Akihito Yasuoka, Toshitada Nagai, Seonmi Lee, Hitonari Miyaguchi, Yoshikazu Saito, Keiko Abe and Tomiko Asakura. Mastication stimuli enhance the learning ability of weaning-stage rats, altering the hippocampal neuron transcriptome and micromorphology. Frontiers in Behavioral Neuroscience-Learning and Memory

Shimada, K., Nohara, M., Yasuoka, A., Kamei, A., Shinozaki, F., Kondo, K., Inoue, R., Kondo, T., and Abe, K. Mouse model of weak depression exhibiting suppressed cAMP signaling in the amygdala, lower lipid catabolism in liver, and correlated gut microbiota.  Frontiers in Behavioral Neuroscience 16, Article 841450 (19 Mar 2022) [DOI]

Ohmori, K., Kamei, A., Watanabe, Y., and Abe, K. Gene expression over time during cell transformation due to non-genotoxic carcinogen treatment of Bhas 42 cells. Int. J. Mol. Sci. 23(6): 3216 (2022, Mar 16).
[DOI]

Kasahara, Y., Yamashita, H., Narukawa, M., Abe, K., & Asakura, T. (2022). 3-Guanidinyl Propanol Enhances Salt Taste via TMC4-Mediated Current. ACS Food Science & Technology.(2022)(2)8  
[DOI]

成川真隆 笠原洋一 朝倉富子 “塩味受容に関わるクロライドチャネルの同定” 化学と生物Vol.60 No.7 Page. 314 – 316 (2022) 国際文献社

Ueda R., Umetani K., Konishi F, Mori A, Nagai T, Asakura H., Funaki J., Abe K and Asakura T*.  Characterization of palatability and ease of deglutition of the five basic tastes were characterized with partial least squares regression analysis using myoelectric potential parameters of the submental muscle
 J. Food Sci. Technol. Res. 28(1) (2022)
[DOI]


2021年

Mimin Zhang, Peng Lu, Tohru Terada, Miaomiao Sui, Haruka Furuta, Kilico Iida, Yukie Katayama, Yi Lu, Ken Okamoto, Michio Suzuki, Tomiko Asakura, Kentaro Shimizu, Fumihiko Hakuno, Shin-Ichiro Takahashi, Norimoto Shimada, Jinwei Yang, Tsutomu Ishikawa, Jin Tatsuzaki and Koji Nagata. Quercetin 3,5,7,3′,4′-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT1.Commun Biol.19;4(1)209 [DOI]

Hiroko Asakura, Takashi Yamakawa, Tomoko Tamura, Reiko Ueda, Shu Taira, Yoshikazu Saito, Keiko Abe, Tomiko Asakura. Transcriptomic and metabolomic analyses provide insights into the upregulation of fatty acid and phospholipid metabolism in tomato fruit under drought stress. J. Agric. Food Chem. 69(9)2894-2905 [DOI]

Satoshi Okubo, Kaede Terauchi, Shinji Okada, Takeo Yamaura, Keiko Abe, Tomiko Asakura. De novo transcriptome analysis and comparative expression profiling of taste-modifying protein neculin-like genes in fruits of Curculigo latifolia and Curculigo capitulata. BMC Genomics 22 347 [DOI]

Zehua Zheng, Kazuhiro Kawakami, Dingkun Zhang, Lumi Negishi, Mohamed Abomosallam, Tomiko Asakura, Koji Nagata and Michio Suzuki. Identification and functional analysis of cadmium-binding protein in the visceral mass of Crassostrea gigas. Scientific reports 11(1)11306-11306 [DOI]

Yoichi Kasahara, Masataka Narukawa, Tomoya Nakagita, Keiko Abe, Takumi Misaka and Tomiko Asakura. Ibuprofen inhibits oral NaCl response through transmembrane channel-like 4. Biochem. Biophys. Res. Commun. 573 76-79 [DOI]

Yoichi Kasahara, Masataka Narukawa, Yohiro Ishimaru, Shinji Kanda, Chie Umatani, Yasunori Takayama, Makoto Tominaga, Yoshitaka Oka, Kaori Kondo, Takashi Kondo, Ayako Takeuchi, Takumi Misaka, Keiko Abe and Tomiko Asakura. TMC4 is novel chloride channel involved in high-concentration salt taste sensation. J Physiol. Sci.71(1), 23 [DOI]

Reiko Ueda, Kana Umetani, Fumiko Konishi, Anju Mori, Toshitada Nagai, Hiroko Asakura, Junko Funaki, Keiko Abe and Tomiko Asakura. Palatability and ease of deglutition of the five basic tastes were characterized with partial least squares regression analysis using myoelectric potential parameters of the submental muscle. J. Food Sci. Technol. Res.

Takase T, Toyoda T, Kobayashi N, Inoue T, Ishijima T, Abe K, Kinoshita H, Tsuchiya Y and Okada S. Dietary iso-α acids prevent acetaldehyde-induced liver injury through Nrf2-mediated gene expression. PLoS ONE16(2) e0246327 [DOI]

Yamamoto S, Kayama T, Noguchi-Shinohara M, Hamaguchi T, Yamada M, Abe K and Kobayashi S. Rosmarinic acid suppresses tau phosphorylation and cognitive decline by downregulating the JNK signaling pathway. Npj Science of Food5(1) [DOI]

Liyanage, Geethika, S.G., Inoue, R., Fujitani, M., Ishijima, T., Shibutani, T., Abe, K., Kishida, T., and Okada, S. Effects of soy isoflavones, resistant starch and antibiotics on polycystic ovary syndrome (PCOS)-like features in letrozole-treated rats. Nutrients13(11), 3759 (2021.10). [DOI]

成川真隆 笠原洋一 朝倉富子 “味の分類-5つの基本味-” 保健の科学63巻4月号「味覚を科学する」杏林書院.

Kasahara, Y., Narukawa, M., Kanda, S., Tominaga, M., Abe, K., Misaka, T., & Asakura, T.
Transmembrane channel-like 4 is involved in pH and temperature-dependent modulation of salty taste 
Biosci. Biotechnol. Biochem 85.11 (2021): 2295-2299 
[PubMed]

Kasahara Y., Narukawa M., Ishimaru Y., Kanda S., Umatani C., Takayama Y., Tominaga M., Oka Y., Kondo K., Kondo T., Takeuchi A., Misaka T., Abe K., Asakura T.
TMC4 is a novel chloride channel involved in high-concentration salt taste sensation
J. Physiol. Sci. (2021) (71),23
[Pubmed] [研究紹介]

Kasahara, Y., Narukawa, M., Nakagita, T., Abe, K., Misaka, T., & Asakura, T.
Ibuprofen inhibits oral NaCl response through transmembrane channel-like 4.
Biochem Biophys Res Commun.(2021) 16,573:76-79
[PubMed]

Asakura H, Yamakawa T, Tamura T, Ueda R, Taira S, Saito Y, Abe K, Asakura T.
Transcriptomic and Metabolomic Analyses Provide Insights into the Upregulation of Fatty Acid and Phospholipid Metabolism in Tomato Fruit under Drought Stress.
J. Agric. Food Chem. (2021) 69,2894-2905.
[PubMed]

Okubo S, Terauchi K, Okada S, Yamaura T, Abe K, Asakura T.
De novo transcriptome analysis and comparative expression profiling of taste-modifying protein neculin-like genes in fruits of Curculigo latifolia and Curculigo capitulata. 
BMC Gonomics. (2021) 22, 347.
[PubMed] [研究紹介]


2020年

山下治之 笠原洋一 朝倉富子 “味覚の宇宙観―ナトリウム摂取と塩味制御の視点から” 「宇宙・医学・栄養学」第2号 篠原出版新社 ISBN 978-4-86705-753-7

Kusunoki K, Hoshi M, Tamura T, Maeda T, Abe K and Asakura T.
Yeast-based reporter assay system for identifying the reqirements of intramembrane proteolysis by signal peptide peptidase of Arabidopsis thaliana.
FEBS Open Bio. (2020) 10(9), 1833-1842.
[PubMed]

Abe A, Tanaka M, Yasuoka A, Saito Y, Okada S, Mishina M, Abe K, Kimura K, Asakura T.
Changes in Whole-Blood microRNA Profiles during the Onset and Treatment Process of Cerebral Infarction: A Human Study.
Int. J. Mol. Sci. (2020) 21(9), 3107.
[PubMed]


2019年

Lu P, Moriwaki Y, Zhang M, Katayama Y, Lu Y, Okamoto K, Terada T, Shimizu K, Wang M, Kamiya T, Fujiwara T, Asakura T, Suzuki M, Yoshimura E, Nagata K.
Functional characterisation of two ferric-ion coordination modes of TtFbpA, the periplasmic subunit of an ABC-type iron transporter from Thermus thermophilus HB8.
Metallomics. (2019) 11(12), 2078-2088.
[PubMed]

Kasahara Y, Sakurai T, Matsuda R, Narukawa M, Yasuoka A, Mori N, Watanabe H, Okabe T, Kojima H, Abe K, Misaka T, Asakura T.
Novel indole and benzothiophene ring derivatives showing differential modulatory activity against human epithelial sodium channel subunits, ENaC β and γ.
Biosci. Biotechnol. Biochem.. (2019) 83(2), 243-250.
[PubMed]

Narisawa T, Nakajima H, Umino M, Kojima T, Yamashita H, Kiribuchi-Otobe C, Yamada M, Asakura T.
Cultivar differences in lipoxygenase activity affect volatile compound formation in dough from wheat mill stream flour.
J. Cereal Sci.. (2019) 87, 231-238.
[ScienceDirect]

Midorikawa K, Kuroda M, Yamashita H, Tamura T, Abe K, Asakura T.
Oryza sativa Brittle Culm 1-like 6 modulates β-glucan levels in the endosperm cell wall.
PloS One. (2019) 14(5), e0127212
[PubMed]


2018年

Yoshinaga K, Nakai Y, Izumi H, Nagaosa K, Ishijima T, Nakano T, Abe K.
Oral administration of edible seaweed Undaria pinnatifida (wakame) modifies glucose and lipid metabolism in rats: a DNA microarray analysis.
Mol. Nutr. Food Res.. (2018) 62, e1700828.
[PubMed]

Izuchi R, Ishijima T, Okada S, Abe K, Nakai Y.
Hepatic fatty acid biosynthesis in KK-Ay mice is modulated by administration of persimmon peel extract: a DNA microarray study.
Food Sci. Nutr.. (2018) 6, 1657-1663.
[PubMed]

Shimazu K, Fukumitsu S, Ishijima T, Toyoda T, Nakai Y, Abe K, Aida K, Okada S, Hino A.
The anti-arthritis effect of olive-derived maslinic acid in mice is due to its promotion of tissue formation and its anti-inflammatory effects.
Mol. Nutr. Food Res.. (2018) 63, e1800543.
[PubMed]

Yanagida K, Igarashi H, Yasuda D, Kobayashi D, Ohto-Nakanishi T, Akahoshi N, Sekiba A, Toyoda T, Ishijima T, Nakai Y, Shojima N, Kubota N, Abe K, Kadowaki T, Ishii S, Shimizu T.
The Gα12/13-coupled receptor, LPA4 limits proper adipose tissue expansion and remodeling in diet-induced obesity.
JCI Insight. (2018) 3, e97293.
[PubMed]

Ogawa, M., Nagai, T., Saito, Y., Miyaguchi, H., Kumakura, K., Abe, K., Asakura, T.
Short-term mastication after weaning upregulates GABAergic signalling and reduces dendritic spine in thalamus.
Biochem Biophys Res Commun. (2018) 498, 621-626.
[PubMed]

Matsuura A, Yoshimura K, Kintsu H, Atsumi T, Tsuchihashi Y, Takeuchi T, Satoh N, Negishi L, Sakuda S, Asakura T, Imura Y, Yoshimura E, Suzuki M.
Structural and functional analyses of calcium ion response factors in the mantle of Pinctada fucata.
J. Struc. Biol.. (2018) 204, 240-249.
[PubMed]


2017年

Tanaka M, Yasuoka A, Shimizu M, Saito Y, Kumakura K, Asakura T, Nagai T.
Transcriptomic responses of the liver and adipose tissues to altered carbohydrate-fat ratio in diet: an isoenergetic study in young rats.
Genes Nutr.. (2017) 12, 10.
[PubMed]

Ogawa M, Yamanashi Y, Takada T, Abe K, d Kobayashi S.
Effect of luteolin on the expression of intestinal cholesterol transporters.
J. Funct. Foods. (2017) 36, 274-279.
[ScienceDirect]

Yoshida K, Yamamoto N, Fujiwara S, Kamei A, Abe K, Nakamura A.
Inhalation of a racemic mixture (R,S)-linalool by rats experiencing restraint stress alters neuropeptide and MHC class I gene expression in the hypothalamus.
Neuroscience Lett.. (2017) 653, 314-319.
[PubMed]

Kozuka C, Shimizu-Okabe C, Takayama C, Nakano K, Morinaga H, Kinjo A, Fukuda K, Kamei A, Yasuoka A, Kondo T, Abe K, Egashira K and Masuzaki H.
Marked augmentation of PLGA nanoparticle-induced metabolically beneficial impact of γ-oryzanol on fuel dyshomeostasis in genetically obese-diabetic ob/ob mice.
Drug Deliv.. (2017) 24, 558-568.
[PubMed]

Tometsuka C, Koyama Y, Ishijima T, Toyoda T, Teranishi M, Takehana K, Abe K, Nakai Y.
Collagen peptide ingestion alters lipid metabolism-related c gene expressions and the unfolded protein response in mouse liver.
Br. J. Nutr.. (2017) 117, 1-11.
[PubMed]

Maeda N, Narukawa M, Ishimaru Y, Yamamoto K, Misaka T, Abe K.
A large increase of sour taste receptor cells in Skn-1-deficient mice does not alter the number of their sour taste signal-transmitting gustatory neurons.
Neuroscience Lett.. (2017) 648, 53-58.
[PubMed]

Kobayashi Y, Sugahara H, Shimada K, Mitsuyama E, Kuhara T, Yasuoka A, Kondo T, Abe K, Xiao J-Z.
Therapeutic potential of Bifidobacterium breve strain A1 for preventing cognitive impairment in Alzheimer’s disease.
Nature Sci. Rep.. (2017) 7, 13510.
[PubMed]

Ishimaru, Y., Kozuka, C., Nakajima, K., and Sasaki, T.
Expanding frontiers in weight-control research explored by young investigators.
J. Physiol. Sci. (2017) 67, 83-95.
[PubMed]

Sharma, R., Ishimaru, Y., Davison, I.G., Ikegami, K., Chien, M.S., You, H., Chi, Q., Kubota, M., Yohda, M., Ehlers, M., and Matsunami, H.
Olfactory receptor accessory proteins play crucial roles in receptor function and gene choice.
Elife. (2017) [Epub ahead of print]
[PubMed]

Takuma, A., Abe, A., Saito, Y., Nito, C., Ueda, M., Ishimaru, Y., Harada, H., Abe, K., Kimura, K., Asakura, T.
Gene Expression Analysis of the Effect of Ischemic Infarction in Whole Blood.
Int J Mol Sci. (2017) 18, 11.
[PubMed]

Narisawa, T., Nakajima, H., Umino, M., Kojima, T., Asakura, T., Yamada, M.
Volatile compounds from Japanese noodles “Udon”, and their formation during noodle-making.
J Food Process Technol. (2017) 8, 700.
[omicsonline]


2016年

Ogasawara Y, Mochimaru S, Ueda R, Ban M, Kabuto S, Abe K.
Preparation of an Aroma Fraction from Dried Bonito by Steam Distillation and Its Effect on Modification of Salty and Umami Taste Qualities.
J. Food Sci.. (2016) 81, 308-316.
[PubMed]

Shinozaki F, Abe T, Kamei A, Watanabe Y, Yasuoka A, Shimada K, Kondo K, Arai S, Kumagai K, Kondo T, Abe K.
Coordination regulation of hepatic and adipose tissue transcriptomes by the oral administration of an amino acid mixture simulating the larval saliva of vespa species.
Genes Nutr.. (2016) 11, 21.
[PubMed]

Soulika M, Kaushik A-L, Mathieu B, Lourenco R, Komisarczuk A.Z, Romano S.A, Jouary A, Lardennois A, Tissot N, Okada S, Abe K, Becker T.S, Kapsimali M.
Diversity in cell motility reveals the dynamic nature of the formation of zebrafish taste sensory organs.
Development. (2016) 143, 2012-2024.
[PubMed]

Chun S, Bamba T, Suyama T, Ishijima T, Fukusaki E, Abe K, Nakai Y.
A high phosphorus diet affects lipid metabolism in rat liver: a DNA microarray analysis.
PLoS ONE. (2016) 11, e0155386.
[PubMed]

Kamei A, Watanabe Y, Shinozaki F, Yasuoka A, Shimada K, Kondo K, Ishijima T, Toyoda T, Arai S, Kondo T, Abe K.
Quantitative deviating effects of maple syrup extract supplementation on the hepatic gene expression of mice fed a high-fat diet.
Mol. Nutr. Food Res.. (2016) 61, e1600477.
[PubMed]

Ushiama, S,. Ishimaru, Y., Narukawa, M., Yoshioka, M., Kozuka, C., Watanabe, N., Tsunoda, M., Osakabe, N., Asakura, T., Masuzaki, H., and Abe, K.
Catecholamines facilitate fuel expenditure and protect against obesity via a novel network of the gut-brain axis in transcription factor Skn-1-deficient mice.
EBioMedicine. (2016) 8, 60-71
[PubMed] [研究紹介]

Kayanuma, Y., Ueda, R., Minami, M., Abe, A., Kimura, K., Funaki, J., Ishimaru, Y., and Asakura, T.
A Predictive Model Based on Surface Electromyography to Assess the Easiness of Deglutition of Dysphagia Diets.
J. Food Process. Technol. (2016) 7, 604.
[J. Food Process. Technol.]

Imai, H., Suzuki-Hashido, N., Ishimaru, Y., Sakurai, T., Yin, L., Pan, W., Ishiguro, M., Masuda, K., Abe, K., Misaka, T., and Hirai H.
Amino acid residues of bitter taste receptor TAS2R16 that determine sensitivity in primates to β-glycosides.
Biophys Physicobiol. (2016) 13, 165-171.
[PubMed]

Tsutsui, K., Otoh, M., Sakurai, K., Suzuki-Hashido, N., Hayakawa, T., Misaka, T., Ishimaru, Y., Aureli, F., Melin, A.D., Kawamura, S., and Imai, H.
Variation in ligand responses of the bitter taste receptors TAS2R1 and TAS2R4 among New World monkeys.
BMC Evol. Biol. (2016) 16, 208
[PubMed]

Abe, A., Nito, C., Sakamoto, Y., Nogami, A., Hokama, H., Takahashi, S., Kirita, K., Ueda, M., Ishimaru, Y., and Kimura, K.
Spontaneous bilateral cervical internal carotid and vertebral artery dissection in a Japanese patient without collagen vascular disease with special reference to single-nucleotide polymorphisms.
J Stroke Cerebrovasc Dis. (2016) 25, e114-7
[PubMed]

Funaki, J., Minami, M., Abe, S., Ueda, R., Eto, W., Kugino, K., Kugino, M., Abe, K., Toko, K., and Asakura, T.
Effect of proteolytic modification on texture and mastication of heat-treated egg white gels.
J. Food Process. Preserv. (2016) [Epub ahead of print]
[Wiley]

Maeda, N., Ohmoto, M., Yamamoto, K., Kurokawa, A., Narukawa, M., Ishimaru, Y., Misaka, T., Matsumoto, I., and Abe, K.
Expression of serotonin receptor genes in cranial ganglia.
Neurosci Lett. (2016) 617, 46-51
[PubMed]


2015年

Ogi, K.Yamashita, H., Terada, T., Homma, R., Shimizu-Ibuka, A., Yoshimura, E., Ishimaru, Y., Abe, K., and Asakura, T.
Long-Chain Fatty Acids Elicit a Bitterness-Masking Effect on Quinine and Other Nitrogenous Bitter Substances by Formation of Insoluble Binary Complexes.
J Agric Food Chem. (2015) 63, 8493-8500
[PubMed]

Ishimaru, Y.
Molecular mechanisms underlying the reception and transmission of sour taste information.
Biosci Biotechnol Biochem. (2015) 79, 171-176
[PubMed]

Suzuki-Hashido, N., Hayakawa, T., Matsui, A., Go, Y., Ishimaru, Y., Misaka, T., Abe, K., Hirai, H., Satta, Y., and Imai, H.
Rapid Expansion of Phenylthiocarbamide Non-Tasters among Japanese Macaques.
PLoS One. (2015) 10, e0132016
[PubMed]

Koizumi, T., Terada, T., Nakajima, K., Kojima, M., Koshiba, S., Matsumura, Y., Kaneda, K., Asakura, T., Shimizu-Ibuka, A., Abe, K., and Misaka, T.
Identification of key neoculin residues responsible for the binding and activation of the sweet taste receptor.
Sci Rep. (2015) 5, 12947
[PubMed]


2014年

Midorikawa, K., Kuroda, M., Terauchi, K., Hoshi, M., Ikenaga, S., Ishimaru, Y., Abe, K., and Asakura, T.
Additional nitrogen fertilization at heading time of rice down-regulates cellulose synthesis in seed endosperm.
PLoS One. (2014) 9, e98738
[PubMed]


2013年

Hoshi, M., Ohki, Y., Ito, K., Tomita, T., Iwatsubo, T., Ishimaru, Y., Abe, K., and Asakura, T.
Experimental detection of proteolytic activity in a signal peptide peptidase of Arabidopsis thaliana.
BMC Biochem. (2013) 14, 16
[PubMed]

Toda, Y., Nakagita, T., Hayakawa, T., Okada, S., Narukawa, M., Imai, H., Ishimaru, Y., and Misaka, T.
Two distinct determinants of ligand specificity in T1R1/T1R3 (the umami taste receptor).
J Biol Chem. (2013) 288, 36863-36877
[PubMed]

Hisatomi, Y., Asakura, K., Kugino, K., Kurokawa, M., Asakura, T., and Nakata K.
Changes in brain tissue and behavior patterns induced by single short-term fasting in mice.
PLoS One (2013) 8, e800857
[PubMed]


2012年

Ishimaru, Y., Abe, M., Asakura, T., Imai, H., and Abe, K.
Expression analysis of taste signal transduction molecules in the fungiform and circumvallate papillae of the rhesus macaque, Macaca mulatta.
PLoS One (2012) 7, e45426
[PubMed] [研究紹介] [Todai Research]

Homma, R.Yamashita, H., Funaki, J., Ueda, R., Sakurai, T., Ishimaru, Y., Abe, K., and Asakura, T.
Identification of bitterness-masking compounds from cheese.
J Agric Food Chem. (2012) 60, 4492-4499
[PubMed]

Yamamoto, K. and Ishimaru, Y.
Oral and extra-oral taste perception.
Semin Cell Dev Biol. (2012) 24, 240-246
[PubMed]

Ishii, S., Kurokawa, A., Kishi, M., Yamagami, K., Okada, S., Ishimaru, Y., and Misaka, T.
The response of PKD1L3/PKD2L1 to acid stimuli is inhibited by capsaicin and its pungent analogs.
FEBS J. (2012) 279, 1857-1870
[PubMed]

Imai, H., Suzuki, N., Ishimaru, Y., Sakurai, T., Yin, L., Pan, W., Abe, K., Misaka, T., and Hirai, H.
Functional diversity of bitter taste receptor TAS2R16 in primates.
Biol Lett. (2012) 8, 652-656
[PubMed]


2011年

Asakura, T., Tamura, T., Terauchi, K., Narikawa, T., Yagasaki, K., Ishimaru, Y., and Abe, K.
Global gene expression profiles in developing soybean seeds.
Plant Physiol Biochem. (2011) 52, 147-153
[PubMed]

Yamamoto, K.Ishimaru, Y., Ohmoto, M., Matsumoto, I., Asakura, T., and Abe, K.
Genetic tracing of the gustatory neural pathway originating from Pkd1l3-expressing type III taste cells in circumvallate and foliate papillae.
J. Neurochem. (2011) 119, 497-506
[PubMed] [研究紹介]

Asakura, T., Miyano, M., Yamashita, H., Sakurai, T., Nakajima, K., Ito, K., Misaka, T., Ishimaru, Y., and Abe, K.
Analysis of the interaction of food components with model lingual epithelial cells: The case of sweet proteins.
Flavour and Fragrance J. (2011) 26, 274-278

Fujimoto, C., Ishimaru, Y., Katano, Y., Misaka, T., Yamasoba, T., Asakura, T., and Abe, K.
The single pore residue Asp(523) in PKD2L1 determines Ca(2+) permeation of the PKD1L3/PKD2L1 complex.
Biochem. Biophys. Res. Commun. (2011) 404, 946-951
[PubMed]

Koizumi, A., Tsuchiya, A., Nakajima, K., Ito, K., Terada, T., Shimizu-Ibuka, A., Briand, L., Asakura, T., Misaka, T., and Abe, K.
Human sweet taste receptor mediates acid-induced sweetness of miraculin.
Proc Natl Acad Sci U S A. (2011) 108, 16819-16824
[PubMed]

Nakajima, K., Koizumi, A., Iizuka, K., Ito, K., Morita, Y., Koizumi, T., Asakura, T., Shimizu-Ibuka, A., Misaka, T., and Abe, K.
Non-acidic compounds induce the intense sweet taste of Neoculin, a taste-modifying protein.
Biosci Biotechnol Biochem. (2011) 75, 1600-1602
[PubMed]

Shibata, M., Ishimatsu-Tsuji, Y., Yokoo, M., Nakai, Y., Abe, K., and Muta-Takada, K.
Effect of oral intake of winged bean extract on a skin lichenification model: evaluation by microarray analysis.
BioFactors37, 421-428
[PubMed]

Ueno, Y., Sakurai, T., Okada, S., Abe, K., and Misaka, T.
Human bitter taste receptors hTAS2R8 and hTAS2R39 with differential functions to recognize bitter peptides.
Biosci. Biotechnol. Biochem. (2011) 75, 1188-1190
[PubMed]

Horio, N., Yoshida, R., Yasumatsu, K., Yanagawa, Y., Ishimaru, Y., Matsunami, H., and Ninomiya, Y.
Sour Taste Responses in Mice Lacking PKD Channels.
PLoS One (2011) 6, e20007
[PubMed]

Matsumoto, I., Ohmoto, M., Narukawa, M., Yoshihara, Y., and Abe, K.
Skn-1a (Pou2f3) specifies taste receptor cell lineage.
Nat. Neurosci. (2011) 14, 685-687
[PubMed]

Nakajima, K., Yokoyama. K., Koizumi, T., Koizumi, A., Asakura, T., Terada, T., Masuda, K., Ito, K., Shimizu-Ibuka, A., Misaka, T., and Abe, K.
Identification and Modulation of the Key Amino Acid Residue Responsible for the pH Sensitivity of Neoculin, a Taste-Modifying Protein.
PLoS One (2011) 6, e19448
[PubMed]

Matsumoto, K., Minami, M., Shinozaki, F., Suzuki, Y., Abe, K., Zenno, S., Matsumoto, S., and Minami, Y.
Hsp90 is involved in the formation of P-bodies and stress granules.
Biochem. Biophys. Res. Commun. (2011) 407, 720-724
[PubMed]

Ito, K., Ito, S., Shimamura, T., Weyand, S., Kawarasaki, Y., Misaka, T., Abe, K., Kobayashi, T., Cameron, A. D., and Iwata, S.
Crystal Structure of Glucansucrase from the Dental Caries Pathogen Streptococcus mutans.
J. Mol. Biol. (2011) 408, 177-186
[PubMed]

Izuchi, R., Nakai, Y., Takahashi, H., Ushiama, S., Okada, S., Misaka, T., and Abe, K.
Hepatic gene expression of the insulin signaling pathway is altered by administration of persimmon peel extract: a DNA microarray study using type 2 diabetic Goto-Kakizaki rats.
J. Agric. Food Chem. (2011) 59, 3320-3329
[PubMed]

Ohmoto, M., Okada, S., Nakamura, S., Abe, K., and Matsumoto, I.
Mutually exclusive expression of G?ia and G?14 reveals diversification of taste receptor cells in zebrafish.
J. Comp. Neurol. (2011) 519, 1616-1629
[PubMed]

Nakai, Y., Sato, B., Ushiama, S., Okada, S., Abe, K., and Arai, S.
Hepatic oxidoreduction-related genes are upregulated by administration of hydrogen-saturated drinking water.
Biosci. Biotechnol. Biochem. (2011) 75, 774-776
[PubMed]

Oda, Y., Ueda, F., Kamei, A., Kakinuma, C., and Abe, K.
Biochemical investigation and gene expression analysis of the immunostimulatory functions of an edible Salacia extract in rat small intestine.
BioFactors. (2011) 37, 31-39
[PubMed]

Ito, K., Sugawara, T., Koizumi, A., Nakajima, K. I., Shimizu-Ibuka, A., Shiroishi, M., Asada, H., Yurugi-Kobayashi, T., Shimamura, T., Asakura, T., Misaka, T., Iwata, S., Kobayashi, T., and Abe, K.
Cysteine-to-serine shuffling using a Saccharomyces cerevisiae expression system improves protein secretion: case of a nonglycosylated mutant of miraculin, a taste-modifying protein.
Biotechnol. Lett. (2011) 33, 103-107
[PubMed]


2010年

Miyano, M., Yamashita, H., Sakurai, T., Nakajima, K., Ito, K., Misaka, T., Ishimaru, Y., Abe, K., and Asakura, T.
Surface plasmon resonance analysis on interactions of food components with a taste epithelial cell model.
J. Agric. Food Chem. (2010) 58, 11870-11875
[PubMed]

Sakurai, T., Misaka, T., Ueno, Y., Ishiguro, M., Matsuo, S., Ishimaru, Y., Asakura, T., and Abe, K.
The human bitter taste receptor, hTAS2R16, discriminates slight differences in the configuration of disaccharides.
Biochem. Biophys. Res. Commun. (2010) 402, 402595-402601
[PubMed]

Narikawa, T., Tamura, T., Yagasaki, K., Terauchi, K., Sanmiya, K., Ishimaru, Y., Abe, K., and Asakura, T.
Expression of the stress-related genes for glutathione S-transferase and ascorbate peroxidase in the most-glycinin-deficient soybean cultivar Tousan205 during seed maturation.
Biosci. Biotechnol. Biochem. (2010) 74, 1976-1979
[PubMed]

Sakurai, T., Misaka, T., Ishiguro, M., Masuda, K., Sugawara, T., Ito, K., Kobayashi, T., Matsuo, S., Ishimaru, Y., Asakura, T., and Abe, K.
Characterization of the beta-D-glucopyranoside binding site of the human bitter taste receptor hTAS2R16.
J. Biol. Chem. (2010) 285, 28373-28378
[PubMed] [研究紹介]

Ishimaru, Y., Katano, Y., Yamamoto, K., Akiba, M., Misaka, T., Roberts, R. W., Asakura, T., Matsunami, H., and Abe, K.
Interaction between PKD1L3 and PKD2L1 through their transmembrane domains is required for localization of PKD2L1 at taste pores in taste cells of circumvallate and foliate papillae.
FASEB J. (2010) 24, 4058-4067
[PubMed] [研究紹介]

Hata, S., Abe, M., Suzuki, H., Kitamura, F., Toyama-Sorimachi, N., Abe, K., Sakimura, K., and Sorimachi, H.
Calpain 8/nCL-2 and Calpain 9/nCL-4 constitute an active protease complex, G-calpain, involved in gastric mucosal defense.
PLoS Genet. (2010) 6, e1001040
[PubMed]

Ito, K., Sugawara, T., Koizumi, A., Nakajima, K.I., Shimizu-Ibuka, A., Shiroishi, M., Asada, H., Yurugi-Kobayashi, T., Shimamura, T., Asakura, T., Misaka, T., Iwata, S., Kobayashi, T., and Abe, K.
Cysteine-to-serine shuffling using a Saccharomyces cerevisiae expression system improves protein secretion: case of a nonglycosylated mutant of miraculin, a taste-modifying protein.
Biotechnol. Lett. (2010) 33, 103-107
[PubMed]

Funaki, J., Tamura, T., Nishinoaki, M., Misaka, T., Eto, W. and Asakura, T.
Utilization of oryzacystatin for regulating the ripening of squid shiokara, a traditional Japanese salted and fermented seafood.
J. Food Sci. (2010) 75, S527-S530
[PubMed]

Ito, K., Sugawara, T., Koizumi, A., Nakajima, K.I., Shimizu-Ibuka, A., Shiroishi, M., Asada, H., Yurugi-Kobayashi, T., Shimamura, T., Asakura, T., Masuda, K., Ishiguro, M., Misaka, T., Iwata, S., Kobayashi, T., and Abe, K.
Bulky high-mannose-type N-glycan blocks the taste-modifying activity of miraculin.
Biochim. Biophys. Acta.. (2010) 1800, 986-992
[PubMed]


2009年

Tamura, T., Kuroda, M., Oikawa, T., Kyozuka, J., Terauchi, K., Ishimaru, Y., Abe, K., and Asakura, T.
Signal peptide peptidases are expressed in the shoot apex of rice, localized to the endoplasmic reticulum.
Plant Cell Rep. (2009) 28, 1615-1621
[PubMed]

Sakurai, T., Misaka,T., Nagai, T., Ishimaru, Y., Matsuo, S., Asakura, T., and Abe, K.
pH-Dependent Inhibition of the Human Bitter Taste Receptor hTAS2R16 by a Variety of Acidic Substances.
J. Agric. Food Chem. (2009) 57, 2508-2514
[PubMed]

Kugino, M., Kugino, K., Tamura, T., and Asakura, T.
Relationship between tissue structural collapse and disappearance of flesh transparency during postmortem changes in squid mantles.
J. Food Sci. (2009) 74, E495-E501
[PubMed]

Morita, Y., Nakajima, K., Iizuka, K., Terada, T., Shimizu-Ibuka, A., Ito, K., Koizumi, A., Asakura, T., Misaka, T., and Abe, K.
pH-dependent structural change in neoculin with special reference to its taste-modifying activity.
Biosci. Biotechnol. Biochem. (2009) 73, 2552-2555
[PubMed]

Matsumoto, I., Asakura, T., Ohmori, T., Tamura, T., and Abe, K.
Cathepsin D-like aspartic proteinase occurring in a maize weevil, Sitophilus zeamais, as its candidate of digestive enzyme.
Biosci. Biotechnol. Biochem. (2009) 73, 2338-2340
[PubMed]

Ishii, S., Misaka, T., Kishi, M., Kaga, T., Ishimaru, Y., and Abe, K.
Acetic acid activates PKD1L3-PKD2L1 channel – a candidate sour taste receptor.
Biochem. Biophys. Res. Commun. (2009) 385, 346-350
[PubMed]

Kiyosaki, T., Asakura, T., Matsumoto, I., Tamura, T., Terauchi, K., Funaki J., Kuroda, M., Misaka, T., and Abe, K.
Wheat cysteine proteases triticain a, b, and c exhibit mutually distinct responses to gibberellin in germinating seeds.
J. Plant Physiol. (2009) 166, 101-106
[PubMed]

Ishimaru, Y. and Matsunami, H.
Transient receptor potential (TRP) channels and taste sensation.
J. Dent. Res. (2009) 88, 212-218. Review
[PubMed]

Ishimaru, Y.
Molecular mechanisms of taste transduction in vertebrates.
Odontology (2009) 97, 1-7. Review
[PubMed]

中島健一郎、古泉文子、朝倉富子、三坂巧
味覚修飾蛋白質ネオクリンの活性化機構と新規甘味蛋白質の開発
蛋白質核酸酵素 (2009) 54, 843-848


2008年

Tamura, T., Asakura, T., Uemura, T., Ueda, T., Terauchi, K., Misaka, T., and Abe, K.
Signal peptide peptidase and its homologs in Arabidopsis thaliana–plant tissue-specific expression and distinct subcellular localization.
FEBS J. (2008) 275, 34-43
[PubMed]

Okubo, S., Asakura, T., Okubo, K., Abe, K., Misaka, T., Akita, T., and Abe K.
Neoculin, a taste-modifying sweet protein, accumulates in ripening fruits of cultivated Curculigo latifolia.
J. Plant Physiol. (2008) 165, 1964-1969
[PubMed]

Shimizu-Ibuka, A., Nakai, Y., Nakamori, K., Morita, Y., Nakajima, K., Kadota, K., Watanabe, H., Okubo, S., Terada, T., Asakura, T., Misaka, T., and Abe, K.
Biochemical and Genomic Analysis of Neoculin Compared to Monocot Mannose-Binding Lectins.
J. Agric. Food Chem. (2008) 56, 5338-5344
[PubMed]

Inada, H., Kawabata, F., Ishimaru, Y., Fushiki, T., Matsunami, H., and Tominaga, M.
Off-response property of an acid-activated cation channel complex PKD1L3-PKD2L1.
EMBO Reports (2008) 9, 690-697
[PubMed]

Nakajima, K., Morita, Y., Koizumi, A., Asakura, T., Terada, T., Ito, K., Shimizu-Ibuka, A., Maruyama, J., Kitamoto, K., Misaka, T., and Abe K.
Acid-induced sweetness of neoculin is ascribed to its pH-dependent agonistic-antagonistic interaction with human sweet taste receptor.
FASEB J. (2008) 22, 2323-2330
[PubMed]

Nishinoaki, M., Asakura, T., Watanabe, T., Kunizaki, E., Matusmoto, M., Tamura, T., Minami, M., Obata, A., Abe, K., and Funaki, J.
Application of an Aspergillus saitoi protease preparation to soybean curd to modify its functional and rheological properties.
Biosci. Biotech. Biochem. (2008) 72, 587-590
[PubMed]

Kataoka, S., Yang, R., Ishimaru, Y., Matsunami, H., Sevigny, J., Kinnamon, J. C., and Finger, T. E.
The Candidate Sour Taste Receptor, PKD2L1, Is Expressed by Type III Taste Cells in the Mouse.
Chem. Senses (2008) 33, 243-254
[PubMed]

Nakajima, K., Asakura, T., Misaka, T., and Abe, K.
Neoculin as a novel sweet protein with taste-modifying activity.
Current Topics in Biotechnology. (2008) 4, 75-82

朝倉富子, 田村倫子, 寺内かえで, 阿部啓子
植物のアスパラギン酸プロテアーゼ
化学と生物 (2008) 46, 702-709

石丸喜朗
脊椎動物における味覚受容の分子基盤
実験医学 (2008) 26, 522-528


2007年

Tamura, T., Terauchi, K., Kiyosaki T., Asakura, T., Funaki, J., Matsumoto, I., Misaka, T., and Abe, K.
Differential expression of wheat aspartic proteinases, WAP1 and WAP2, in germinating and maturing seeds.
J. Plant Physiol164, 470-477.
[PubMed]

Ito, K., Asakura, T., Morita, Y., Nakajima, K., Koizumi, A., Shimizu-Ibuka, A., Masuda, K., Ishiguro, M., Terada, T., Maruyama, J., Kitamoto, K., Misaka, T., and Abe, K.
Microbial production of sensory-active miraculin.
Biochem. Biophys. Res. Commun360, 407-411.
[PubMed]

Koizumi, A., Nakajima, K., Asakura, T., Morita, Y., Ito, K., Shmizu-Ibuka, A., Misaka, T., and Abe, K.
Taste-modifying sweet protein, neoculin, is received at human T1R3 amino terminal domain.
Biochem. Biophys. Res. Commun358, 585-589.
[PubMed]

Oike, H., Nagai, T., Furuyama, A., Okada, S., Aihara, Y., Ishimaru, Y., Marui, T., Matsumoto, I., Misaka, T., and Abe, K.
Characterization of ligands for fish taste receptors.
J. Neurosci27(21), 5584-5592.
[PubMed]

Kiyosaki, T., Matsumoto, I., Asakura, T., Funaki, J., Kuroda, M., Misaka, T., Arai, S., and Abe, K.
Gliadain, a gibberellin-inducible cysteine proteinase occurring in germinating seeds of wheat, Triticum aestivum L., specifically digests gliadin and is regulated by intrinsic cystatins.
FEBS J274, 1908-1917.
[PubMed]

Aoki, F., Honda, S., Kishida, H., Kitano, M., Arai, N., Tanaka, H., Yokota, S., Kaku, A., Nakagawa, K., Asakura, T., Nakai, Y., and Mae, T.
Suppression by licorice flavonoids of abdominal fat accumulation and body weight gain in high-fat diet-induced obese C57BL/6J mice.
Biosci. Biotech. Biochem71, 206-214.
[PubMed]


2006年

Ishimaru, Y., Inada, H., Kubota, M., Zhuang, H., Tominaga, M., and Matsunami, H.
Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor.
Proc. Natl. Acad. Sci. USA 103(33), 12569-12574.
[PubMed]

Nakajima, K., Asakura, T., Oike, H., Morita, Y., Shimizu-Ibuka, A., Misaka, T., Sorimachi, H., Arai, S., and Abe, K.
Neoculin, a taste-modifying protein, is recognized by human sweet taste receptor.
Neuroreport 17, 1241-1244.
[PubMed]

Terauchi, K., Asakura, T., Ueda, H., Tamura, T., Tamura, K., Matsumoto, I., Misaka, T., Hara-Nishimura, I., and Abe, K.
Plant-specific insertions in the soybean aspartic proteinases, soyAP1 and soyAP2, perform different functions of vacuolar targeting.
J. Plant Physiol163, 856-862.
[PubMed]

Nakajima, K., Asakura, T., Maruyama, J., Morita, Y., Oike, H., Shimizu-Ibuka, A., Misaka, T., Sorimachi, H., Arai, S., Kitamoto, K., and Abe, K.
Extracellular production of neoculin, a sweet-tasting heterodimeric protein with taste-modifying activity, by Aspergillus oryzae.
Appl. Environ. Microbiol72, 3716-3723.
[PubMed]

Shimizu-Ibuka, A., Morita, Y., Terada, T., Asakura, T., Nakajima, K., Iwata, S., Misaka, T., Sorimachi, H., Arai, S., and Abe, K.
Crystal structure of neoculin: insights into its sweetness and taste-modifying activity.
J. Mol. Biol.359, 148-158.
[PubMed]


2005年

Ishimaru, Y., Okada, S., Naito, H., Nagai, T., Yasuoka, A., Matsumoto, I., and Abe, K.
Two families of candidate taste receptors in fishes.
Mech. Dev122, 1310-1321.
[PubMed]

Nakai, Y., Okada, S., Matsumoto, I., Asakura, T., and Kimura, H.
Time-course characteristics for the digestion of endogenous as well as exogenous protein in the small intestine: a case study with rats fed a [15N]-soy protein isolate.
Biosci. Biotechnol. Biochem69, 855-856.
[PubMed]


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